A very sincere “thank you” to all our early investors!!! If you have any questions or comments, please post them in the “Comments” section near the bottom of the EPR-Technologies’ Campaign Page, and I will reply within 24 hours. Also, as mentioned on the EPR Campaign Page, it is very important not to confuse the use of mild hypothermia with EPR’s profound hypothermia. Mild and profound hypothermia have very different medical indications for use, different techniques, and very different treatment goals. And EPR’s profound hypothermia is a new, unique, revolutionary emergency intervention. Just to make this point as clear as possible, below is a summary of distinguishing features for mild versus profound hypothermia.
MILD HYPOTHERMIA FEATURES: (1) Currently used for severe heart attack and cardiac arrest following successful CPR, but the patient remains unconscious; (2) Mild hypothermia cooling to 33⁰C-36⁰C (91.4⁰F-96.8⁰F) is the optimal treatment to prevent brain damage or other complications from inadequate oxygen supply during and immediately after the cardiac arrest and CPR; (3) Mild cooling should be initiated within 2-4 hours after successful CPR; (4) Cooling time to target temperature should be achieved in approximately 1 hour; (5) Mild hypothermia may be achieved with 1-liter cold saline intravenous (IV) infusion, followed by surface cooling body wraps, cooling pads, endovascular cold probe, or ice packs; (6) During mild hypothermia, the heart continues to beat, breathing continues, and brain waves remain present; (7) Patient is kept sedated to prevent shivering; (8) Mild hypothermia is maintained for 24-36 hours, then the patient is slowly rewarmed; and (9) Potential benefits for mild hypothermia are also being studied in traumatic brain injury, neuroprotection, and stroke.
PROFOUND HYPOTHERMIA FEATURES: (1) EPR’s profound hypothermia is to be used following failed CPR in severe trauma + exsanguination cardiac arrest, sudden cardiac arrest, and heart attack + ventricular fibrillation (VF) unresponsive to defibrillation; (2) EPR may also be used in cardiac surgical emergencies, toxin, venom, poison and chemical/biological warfare agent exposures, opioid overdoses, drowning, and respiratory insufficiencies that lead to unresuscitable cardiac arrest; (3) EPR is designed to save currently unrecoverable lives when CPR fails; (4) Profound cooling is in the range of 5⁰C-15⁰C (41⁰F-59⁰F); (5) Cooling time to target temperature must be very rapid to prevent vital organ damage; (6) Profound hypothermia is achieved within in 7-12 minutes using 20-40 liters of ice-cold saline (potentially plus additives) rapidly infused into a major artery or the proximal descending aorta followed by surgical & medical interventions; (7) The 20-40 liters of ice-cold saline is infused at a minimum of 4-liters per minute; (8) With profound cooling, no heartbeat, no breathing, and no brain waves are present, and no oxygen delivery is necessary for cellular viability to continue at profound hypothermic temperatures; (9) EPR buys critical time up to 3 hours for necessary surgical and medical treatments prior to placing the patient on cardiopulmonary bypass (CPB) for rewarming; (10) The EPR clinical trial is currently underway at Maryland Shock Trauma in Baltimore; and (11) EPR’s profound hypothermia is a new, unique, revolutionary, emergency medical intervention. Thanks, Lyn Yaffe, EPR-Technologies, Inc.