Many thanks to our early investors, very much appreciated!!! Here’s some more history about Dr. Peter Safar, M.D. (1924-2003), considered the “father of cardiopulmonary resuscitation” (CPR), and the original driving force behind Emergency Preservation and Resuscitation (EPR). In the very early days during the development of mouth-to-mouth resuscitation, supported by the US Army, much like EPR research has been supported by the US Army, a video was produced comparing the different techniques at the time for respiratory resuscitation. The conclusive result of the research was that the mouth-to-mouth resuscitation technique developed by Peter Safar was the best approach. The video shows a young Peter Safar discussing the various respiratory resuscitation techniques studied at that time. Dr. Safar’s discussion may be seen at the YouTube URL (https://youtu.be/FG2qy4CQy0Q) just in case the embedded video below does not play on your browser. Please excuse the somewhat high-pitched audio which was typical of many audio recordings in those years. The video shows CPR history-making research events from decades ago!!! Thanks, Lyn Yaffe, EPR-Technologies, Inc.

Many thanks to our early investors, very much appreciated!!! Back in 2019 WIRED Magazine in the UK cited “19 things that made the world a better place”. Emergency Preservation and Resuscitation (EPR) made the list. Below is an image of the EPR portion of the article or go to the URL https://www.wired.co.uk/article/2019-positive-news and scroll down the article to find “Humans placed in suspended animation.” In the article, the use of the term “A&E” means Accident and Emergency, it’s the UK equivalence of Emergency Room in the US. EPR continues to strive to “make the world a better place.”  Thanks, Lyn Yaffe, EPR-Technologies, Inc.

Many thanks to our early investors, very much appreciated!!! My EPR video overview describing the efforts and significance of a successful EPR-Technologies endeavor has been placed at the top of the EPR StartEngine Campaign Page. If you have not visited our StartEngine Campaign Page recently, please take a look at my video and provide any comments or questions, I will reply with 24 hours at most. Thanks, Lyn Yaffe, EPR-Technologies, Inc.

Many thanks to our early investors!!! Freedom House Ambulance Service was a pioneering social and emergency medical project that trained unemployed Black citizens in Pittsburgh during the late 1960s and early 1970s to provide what was then state-of-the-art prehospital emergency medical care. The Freedom House leaders were Dr. Peter Safar (1924-2003), the “father of cardiopulmonary resuscitation (CPR)” and pioneering force behind Emergency Preservation and Resuscitation (EPR), and his protégé, Dr. Nancy Caroline. The success of Freedom House demonstrated national standards for paramedic training and equipment. However, the Freedom House program ended abruptly in 1975 when Pittsburgh's city administration at the time cited economic constraints for continued support of Freedom House. However, African Americans and white citizens, as well as local newspapers, instead understood the city's diminishing support of the program in racial terms. Nevertheless, Freedom House was the forerunner of modern paramedic services and is a model for EPR point-of-injury care in the future with successful funding support. The story of Freedom House and Dr. Safar’s role may be seen at the YouTube URL (https://youtu.be/SvOHFMQRgAY) just in case the embedded video does not play on your browser, and a published journal reference is: J Hist Med Allied Sci, 2019 Oct 1;74(4):440-466. doi: 10.1093/jhmas/jrz041, at https://pubmed.ncbi.nlm.nih.gov/31592527/. Thanks, Lyn Yaffe, EPR-Technologies, Inc.

I will be interviewed tomorrow, 23 March 2022, at 4:00 PM EDT, for about 10 minutes, to briefly discuss EPR-Technologies and rapid profound hypothermia on the podcast radio station www.chatandspinradio.com, so if you’re available, please tune in!!! And many thanks to our early investors, very much appreciated!!! Lyn Yaffe, EPR-Technologies, Inc.

Many thanks to our early investors!!! EPR Clinical Trial Design - The Emergency Preservation and Resuscitation (EPR) clinical trial is designed to test the feasibility and safety of inducing rapid profound hypothermia to enable delayed resuscitation in trauma victims who have suffered cardiac arrest. Cardiac arrest trauma victims are only enrolled in the EPR feasibility clinical trial when the subjects meet the inclusion criteria and medical/surgical personnel trained in EPR procedures are available. Trauma victims may be enrolled in the EPR clinical trial if they meet all of the following criteria: (1) At least 18 years of age; (2) Trauma is a penetrating injury; (3) At least one sign of life including pulse, respirations, reactive pupils, or spontaneous movement is present within the initial 5 minutes of arrival at the trauma center, but disappear necessitating initiation of cardiopulmonary resuscitation attempts; (4) No pulses are present in large arteries, including the carotid and femoral arteries; and (5) Trauma victims remain pulseless after emergency thoracotomy and at least 5 minutes of open-chest resuscitation attempts. Trauma victims are excluded from the EPR clinical trial if (1) Significant head trauma is visible or suspected; (2) Trauma victim’s cardiac rhythm demonstrates electrical asystole; and (3) External assessment of the injuries suggests massive tissue trauma or blunt trauma involving multiple body regions. EPR Clinical Trial Specific Aims – (1) To test the use of rapid profound hypothermia in circulatory cardiac on patients who have no chance of survival with current therapies; (2) To test EPR by rapidly inducing profound hypothermia through the infusion of ice-cold saline via a large-bore catheter placed into the proximal, descending aorta to attain a tympanic membrane temperature between 5⁰C-15⁰C maximum (41⁰F-59⁰F), and following surgical repairs/hemostasis, delayed resuscitation may be accomplished with cardiopulmonary bypass (CPB); and (3) To examine the safety and efficacy of EPR rapid profound hypothermia and delayed resuscitation, with the development of multiple organ system dysfunction, neurologic function, and survival being used as secondary endpoints. Thanks, Lyn Yaffe, EPR-Technologies, Inc.

Many thanks to our early investors, very much appreciated!!! EPR-Technologies is very happy to announce that William “Tedd” Howsare is now managing our out-reach via social media, including Facebook, Instagram, and LinkedIn, as well as updating the EPR website, press releases, and other marketing endeavors to get information about our EPR StartEngine Campaign raise widely disseminated. Tedd is very experienced with crowdfunding raises, and related marketing and investment strategies to achieve a successful raise. I will periodically post updates about Tedd’s ongoing efforts on behalf of EPR-Technologies. Thanks, Lyn Yaffe, EPR-Technologies, Inc.

A big “thank you” to all our early investors!!! Some more history about Dr. Peter Safar, M.D. (1924-2003), considered the “father of cardiopulmonary resuscitation” (CPR), and the original driving force behind Emergency Preservation and Resuscitation (EPR). Dr. Safar established mouth-to-mouth breathing as an integral procedure with chest compressions for successful cardiopulmonary resuscitation (CPR). Attached is an historic video of Dr. Safar performing early experiments of mouth-to-mouth breathing on a research laboratory associate whose respiratory muscles were paralyzed with a drug for the demonstration, “boldly going where no one had gone before”. The mouth-to-mouth breathing, being performed by Dr. Safar, may be seen at the YouTube URL (https://youtu.be/3PVFOMPCOz4) just in case the embedded video does not play on your browser. Thanks, Lyn Yaffe, EPR-Technologies, Inc.

Thanks to all our early investors!!! Three adults, 2 buried in avalanches and 1 submerged in ice-cold water in a glacier crevasse, suffered accidental profound hypothermia and total cardiorespiratory arrest, lasting 2-1/2 to 4 hours prior to resuscitation. The patients fully recovered their mental and physical abilities following re-warming and delayed resuscitation. While these anecdotal profound hypothermia cases occurred in otherwise healthy adults, the cases demonstrate that prolonged profound hypothermia, in and of itself, does not preclude delayed resuscitation success and full recovery. The goal of EPR-Technologies is to demonstrate that the same successful results may be achieved in cardiopulmonary arrest victims of severe trauma, sudden cardiac arrest, and other causes of currently unresuscitable cardiac arrest.  Read the published science article about these 3 cited cases at: https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC1352533/. Thanks, Lyn Yaffe, EPR-Technologies, Inc.

A very sincere “thank you” to all our early investors!!! If you have any questions or comments, please post them in the “Comments” section near the bottom of the EPR-Technologies’ Campaign Page, and I will reply within 24 hours. Also, as mentioned on the EPR Campaign Page, it is very important not to confuse the use of mild hypothermia with EPR’s profound hypothermia. Mild and profound hypothermia have very different medical indications for use, different techniques, and very different treatment goals. And EPR’s profound hypothermia is a new, unique, revolutionary emergency intervention. Just to make this point as clear as possible, below is a summary of distinguishing features for mild versus profound hypothermia.

MILD HYPOTHERMIA FEATURES: (1) Currently used for severe heart attack and cardiac arrest following successful CPR, but the patient remains unconscious; (2) Mild hypothermia cooling to 33⁰C-36⁰C (91.4⁰F-96.8⁰F) is the optimal treatment to prevent brain damage or other complications from inadequate oxygen supply during and immediately after the cardiac arrest and CPR; (3) Mild cooling should be initiated within 2-4 hours after successful CPR; (4) Cooling time to target temperature should be achieved in approximately 1 hour; (5) Mild hypothermia may be achieved with 1-liter cold saline intravenous (IV) infusion, followed by surface cooling body wraps, cooling pads, endovascular cold probe, or ice packs; (6) During mild hypothermia, the heart continues to beat, breathing continues, and brain waves remain present; (7) Patient is kept sedated to prevent shivering; (8) Mild hypothermia is maintained for 24-36 hours, then the patient is slowly rewarmed; and (9) Potential benefits for mild hypothermia are also being studied in traumatic brain injury, neuroprotection, and stroke.

PROFOUND HYPOTHERMIA FEATURES: (1) EPR’s profound hypothermia is to be used following failed CPR in severe trauma + exsanguination cardiac arrest, sudden cardiac arrest, and heart attack + ventricular fibrillation (VF) unresponsive to defibrillation; (2) EPR may also be used in cardiac surgical emergencies, toxin, venom, poison and chemical/biological warfare agent exposures, opioid overdoses, drowning, and respiratory insufficiencies that lead to unresuscitable cardiac arrest; (3) EPR is designed to save currently unrecoverable lives when CPR fails; (4) Profound cooling is in the range of 5⁰C-15⁰C (41⁰F-59⁰F); (5) Cooling time to target temperature must be very rapid to prevent vital organ damage; (6) Profound hypothermia is achieved within in 7-12 minutes using 20-40 liters of ice-cold saline (potentially plus additives) rapidly infused into a major artery or the proximal descending aorta followed by surgical & medical interventions; (7) The 20-40 liters of ice-cold saline is infused at a minimum of 4-liters per minute; (8) With profound cooling, no heartbeat, no breathing, and no brain waves are present, and no oxygen delivery is necessary for cellular viability to continue at profound hypothermic temperatures; (9) EPR buys critical time up to 3 hours for necessary surgical and medical treatments prior to placing the patient on cardiopulmonary bypass (CPB) for rewarming; (10) The EPR clinical trial is currently underway at Maryland Shock Trauma in Baltimore; and (11) EPR’s profound hypothermia is a new, unique, revolutionary, emergency medical intervention. Thanks, Lyn Yaffe, EPR-Technologies, Inc.

A hearty thanks to our early investors!! Help spread the EPR word to family and friends!! Suspended animation is much more familiar in science fiction than in medicine, but EPR researchers did use the term suspended animation to describe the impact of rapid profound hypothermia in early experiments. Like the current, preferable term “Emergency Preservation and Resuscitation” (EPR), suspended animation may be defined as treatment to preserve the viability of the entire organism during ischemia or lack of oxygen, such as during cardiac arrest or severe shock. The goal of both the early experiments in suspended animation, and now true for EPR, was to induce rapid profound hypothermia. If immediate preservation sustains viability of the brain and body, then there is critical time for transport and surgical repairs to be followed by restoration of blood volume and resuscitation, using cardiopulmonary bypass (CPB). The attached video has a little fun with the term suspended animation, then discusses the serious efforts in Emergency Preservation and Resuscitation. The YouTube URL (https://youtu.be/7LWXeEUDhY4) is provided just in case the embedded video does not play on your browser. Thanks, – Lyn Yaffe, EPR-Technologies, Inc.

Hello!! Many thanks to our early investors, very much appreciated. Now, together, we are dedicated to saving lives!! I wanted to begin these updates with some history about Dr. Peter Safar, M.D. (1924-2003), considered the “father of cardiopulmonary resuscitation” (CPR), and the original driving force behind Emergency Preservation and Resuscitation (EPR). Dr. Safar was interviewed by ABC News years ago, saying a few words about cooling and forecasting the research success that was to become EPR. Attached is that ABC News interview and its YouTube URL (https://youtu.be/c4u79mx49ns) just in case the embedded video does not play on your browser. Thanks, – Lyn Yaffe, EPR-Technologies, Inc.